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Spinal Injury Foundation, Board Member

Sean S. Kohles, PhD - Bioengineer

Dr. Kohles is a Bioengineer in Portland, Oregon, and joined the SIF Board of Directors in 2007. He is as a Research Associate Professor of Mechanical & Materials Engineering at Portland State University where he directs the Reparative Bioengineering Laboratory in the Northwest Center for Engineering, Science & Technology. In addition, he is an Adjunct Associate Professor of Surgery at the Oregon Health & Science University. Dr. Kohles is the Director of Kohles Bioengineering, an independent, consulting/research entity.

Before arriving in Portland in 2001, he was a joint faculty member at Worcester Polytechnic Institute, the University of Massachusetts Medical School, and Tufts University School of Veterinary Medicine. Dr. Kohles has published over 120 journal and conference papers in the broad areas of biomaterials, tissue, and cellular biomechanical engineering with applications in spinal and joint regenerative medicine. His research is supported by the National Institutes of Health and the National Science Foundation.

 He is an active member a number of professional societies including the Orthopaedic Research Society, the Biomedical Engineering Society, the American Society of Mechanical Engineers, and the American Society of Biomechanics. These memberships include service on the Editorial Boards for the Journal of Biomechanics and the Annals of Biomedical Engineering. He completed a doctoral degree in Bioengineering and BS/MS degrees in Engineering Mechanics all at the University of Wisconsin-Madison.

Technical Specialties:

Bioengineering; Biomechanics (Tissue Mechanics and Kinesiology); Biomaterials and Tissue Engineering Development; Biomedical Technology Design (Orthopedic, Dental, Cardiovascular, Minimally Invasive); Biostatistics and Mathematical Modeling.

Current Research:

Cartilage Tissue Engineering Model Development (funded by NIH), Single-Cell Biomechanics (funded by NSF).

Current Appointments:

1987-present Director,
Kohles Bioengineering, Portland, OR;
2002-present Adjunct Associate Professor,
Mechanical & Materials Engineering, Portland State University, Portland, OR;
Mechanical Engineering, Oregon State University, Corvallis, OR; and
Surgery, Oregon Health & Science University, Portland, OR
2002-present, Associate Editor, Annals of Biomedical Engineering
2005-present, Editorial Consultant, Journal of Biomechanics
2007-present, Director, Spinal Injury Foundation

Previous Experience:

1997-2001 Assistant Professor, Departments of Biomedical Engineering, Mechanical Engineering, Biology & Biotechnology, Worcester Polytechnic Institute, Worcester, MA
1998-2001 Adjunct Assistant Professor, Department of Clinical Science, Tufts University School of Veterinary Medicine, Grafton, MA, and Departments of Physiology and Orthopedics & Rehabilitation, University of Massachusetts Medical School, Worcester, MA
1996-1997 Visiting Assistant Professor, Department of Exercise and Movement Science, University of Oregon, Eugene, OR
1996 Collaborator, Departments of Mechanical Engineering and Bioengineering, University of Washington, Seattle, WA
1994-1995 Honorary Postdoctoral Fellow, Division of Orthopedic Surgery, University of Wisconsin, Madison, WI
1987-1994 Research Assistant, Division of Orthopedic Surgery & School of Veterinary Medicine, University of Wisconsin, Madison, WI
1987-1988, 1993-1994 Teaching Assistant, Departments of Engineering Mechanics & Kinesiology, University of Wisconsin, Madison, WI
1985-1987 Laboratory Assistant, Department of Engineering Mechanics, University of Wisconsin, Madison, WI

Education:

1994 PhD, Bioengineering, University of Wisconsin-Madison
1988 MS, Engineering Mechanics, University of Wisconsin-Madison
1987 BS, Engineering Mechanics, University of Wisconsin-Madison

Journal Articles:

Selected from Recent Peer Reviewed Publications:

CG Wilson, LJ Bonassar, SS Kohles. "Modeling the Dynamic Composition of Engineered Cartilage," Archives of Biochemistry and Biophysics, 408(2):246-254, 2002.

RM Stach, SS Kohles. "A Meta-Analysis Examining the Clinical Survivability of Machined-Surfaced and Osseotite Implants in Poor-Quality Bone," Implant Dentistry: International Journal of Oral Implantology, 12(1):87-96, 2003.

R Roy, SS Kohles, V Zaporojan, GM Peretti, J Xu, MA Randolph, LJ Bonassar. "Bending behavior of native and engineered, auricular and costal cartilage," Journal of Biomedical Materials Research, 68A(4):597-602, 2004.

SS Kohles, DA Kohles, AP Karp, VM Erlich, NL Polissar. "Time-Dependent Surgical Outcomes Following Cauda Equina Syndrome Diagnosis: Comments on a Meta-Analysis," Spine, 29(11):1281-1287, 2004.

AK Saha, J Mazumdar, SS Kohles. "Prediction of Growth Factor Effects on Engineered Cartilage Composition Using Deterministic and Stochastic Modeling," Annals of Biomedical Engineering, 32(6):871-879, 2004.

SS Kohles, MB Clark, CA Brown, JN Kenealy, "Direct Assessment of Profilometric Roughness Variability from Typical Implant Surface Types," International Journal of Oral and Maxillofacial Implants, 19(4):510-516, 2004.

S Feldman, N Boitel, D Weng, SS Kohles, RM Stach. "Five-Year Survival Distributions of Short-Length (10 mm or less), Machined-Surfaced and Osseotite Implants," Clinical Implant Dentistry and Related Research, 6(1):16-23, 2004.

AK Saha, J Mazumdar, SS Kohles. "Dynamic Matrix Composition in Engineered Cartilage with Stochastic Supplementation of Growth Factors," Australasian Physical & Engineering Sciences in Medicine, 28(2):97-104, 2005.

SS Kohles, CG Wilson, LJ Bonassar. "A Mechanical Composite Spheres Analysis of Engineered Cartilage Dynamics," ASME Journal of Biomechanical Engineering, in press, 2007.

SS Kohles, RW Mangan, E Stan, J McNames. "A First-Order Mechanical Model of Traumatized Craniovascular BioDynamics," ASME Journal of Medical Devices, 1(1):89-95, 2007.

SS Kohles, KN Gregorczyk, TC Phillips, LT Brody, JF Orwin, R Vanderby Jr. "Concentric and Eccentric Shoulder Rehabilitation Biomechanics," Journal of Engineering in Medicine: Proceedings of the Institution of Mechanical Engineers Part H, in press, 2007

 

Kohles Bioengineering is an independent, business entity which conducts biomechanical research, design, and analysis to support industry and federal agency contracts/grants. Design, Discovery, and Dissemination (D3) are the key objectives of this organization. Please follow this link to explore the background, services, and productivity of this effort