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Fibromyalgia, Chronic Fatigue, Pain, Inflammation and Diet

By Christopher J. Centeno, MD

 

>Im I'm always asked by patients if they can change anything to help their pain while theyre being treated at our clinic. Many patients who have been diagnosed with Fibromyalgia Syndrome (FMS) have inflammatory type symptoms in multiple joints (hands, shoulders, hips, knees, ankles, etc) To help this type of pain, there is strong circumstantial evidence (as well as our own anecdotal and clinical experience), that chronic inflammation in many patients may be strongly linked to diet.

In order to understand this topic, some background is needed. Its been known for several years that some people are likely genetically predisposed to develop type II diabetes.[1-4] To understand what happens to these people as they age, you need to understand how the body handles sugars. One type of sugar, Glucose, is critical to brain functioning and acts as the coal for the furnace of the body. We need glucose to live. When we eat sugar or starches in our diet, these are broken down to glucose. This glucose has to get into cells to be used effectively as coal for the furnace. A hormone called insulin is the key that unlocks the door for the glucose to enter all of your cells and be used as energy. Some people produce too much insulin in response to sugars in the diet. These patients develop what is now being called the Metabolic Syndrome.[5-9] Over time, these massive amounts of secreted insulin cause the cells to become less sensitive to insulin and these patients develop insulin resistance.

This is the first step toward full blown type II diabetes or as I like to call it, a diabetic in training. These patients usually have normal or near normal fasting glucose levels, so they are rarely diagnosed with anything at this point. These patients usually become overweight in middle age and are noted to have high triglycerides and blood lipids and over time will develop high blood pressure. They are usually tired all the time, as their blood sugar levels drop substantially after a high glycemic meal (lots of carbs and/or sugar).

What does all of this have to do with pain? Its all about the inflammation. In last 5 years, hundreds s of studies have been completed finding strong links between heart disease and inflammation. One measure of total body levels of inflammation is C-reactive protein or CRP. Patients with the Metabolic Syndrome or diabetics in training have elevated CRP levels.[8, 10-13] While not much study has been focused on how diet can impact osteoarthritis, elevated inflammatory markers have been found in several studies of patients with hip, knee, and erosive hand osteoarthritis.[14-17] It would seem logical then that patients who have early insulin resistance may be able to control both onset of diabetes and inflammation by dietary changes.

What does all of this mean? If you have rapidly gained weight in middle age (like many of us) you may be rapidly developing insulin resistance. You should consider yourself a diabetic in training. If you change your diet, you will likely lose weight and stave off the development of type II diabetes and this will definitely have a great positive health impact. This may also reduce your pain or make it more manageable (through weight loss and less mechanical overload as well as through reducing inflammation in your body). How should you eat? The first rule is simple: AVOID THE WHITE STUFF! Avoid white sugar and white flour. The second rule is also simple; ITS ALL ABOUT YOUR BLOOD SUGAR!

 1. Avoid white flour. This also means that you significantly limit bread intake to small amounts of true whole grain bread or some of the low carb breads on the market. This is as little as 2-4 slices of bread (or the equivalent) per day. This means no cakes, pastries, or other concoctions made with white flour. Your intake of any of these types of sweets (even if made with whole wheat flour) should be significantly limited. 

2.Avoid all candy.

3.The best sweetener to use is natural honey (not processed big company brands that add sugar, but old fashioned small farm honey from real bees). Several studies have shown that small amount of natural honey have a stabilizing effect on blood sugar.[18, 19] Depending on how you feel about artificial sweeteners, you can also use small amounts of Equal or Splenda (but these can also elevate blood sugar).

4. Caffeine will drop your blood sugar by triggering massive insulin releases, avoid this as much as possible. That means pretty much anything they sell at Starbucks is off limits. This also means that teas and diet coals are also off limits. Green teas seem to be a little easier on blood sugar levels, but not that much, so avoid drinking significant quantities of these as well. In order to accomplish this part of the diet in our busy world, you have to take care of yourself and rest when you are tired. We've gotten into the habit of tanking up on caffeine when were tired and not resting, this is bad for your pain, blood sugar, and your health.

5. Avoid potatoes and other very high carbohydrate fruits and vegetables (a lot of carrots, bananas), eats lots of all other kinds of fruits and vegetables.

6. All pasta is off limits.

7. While saturated fat has been demonized by the medical community, the research showing that it has negative health effects is very weak. In fact, the largest funded dietary study (WHI or Women's Health Initiative) failed to show any benefits to avoiding saturated fats. Fats will help stabilize blood sugar, so dont avoid natural fats.

 8. In our parents day, if you baked a cake or cookies, they went bad after a week. In the 1950s the food industry fixed that by superheating the oils to create a new substance that had never existed. It extended the shelf life of foods so that you could keep crackers on the shelves for years without them going bad. However, it also introduced a completely foreign substance into the food supply. For general health, avoid trans fats like the plague! These are hydrogenated or partially hydrogenated oils. They are found in most foods that have a substantial shelf life, so read the labels! While this may not have much to do with pain, these types of fats are a substantial heart health risk among just about all studies. To get an idea of how to avoid these fats, go into your cabinets and spend 10 minutes reading labels, you will be surprised at how these fats are in almost everything.

9. If you feel tired after a meal or are ravenously hungry before a meal or when you wake up, you have exceeded your glycemic load. This means that you ate more starchy or sugary carbs than your body can handle. Avoid these foods and/or cut back severely on them. True hunger is a deep gnawing realization that you should probably eat. An insulin overload from eating the wrong foods is the realization that you would gladly knock over a convenience store if you could just eat something now! You should study yourself after meals and in the mornings to learn the difference between these two sensations.

10. Like everything you've heard, exercise will help you control weight and will also help you control blood sugar. How do you exercise when you hurt all the time? Warm water pool therapy is a great start for many patients.

For more information about how to eat this way, see www.amazon.com and search in books under glycemic index. Many great books will come up. Eating this way will help you lose weight, feel better with less fatigue, and may just help your joint pain!

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10. Bo, S., et al., Does C-reactive protein identify a subclinical metabolic disease in healthy subjects? Eur J Clin Invest, 2005. 35(4): p. 265-70.

11. Florez, H., et al., C-reactive protein is elevated in obese patients with the metabolic syndrome. Diabetes Res Clin Pract, 2006. 71(1): p. 92-100.

12. Gonzalez, A.S., et al., Metabolic syndrome, insulin resistance and the inflammation markers C-reactive protein and ferritin. Eur J Clin Nutr, 2006. 60(6): p. 802-9.

 13. Temelkova-Kurktschiev, T., et al., Subclinical inflammation is strongly related to insulin resistance but not to impaired insulin secretion in a high risk population for diabetes. Metabolism, 2002. 51(6): p. 743-9.

14. Garnero, P., et al., Cross-sectional association of 10 molecular markers of bone, cartilage, and synovium with disease activity and radiological joint damage in patients with hip osteoarthritis: the ECHODIAH cohort. J Rheumatol, 2005. 32(4): p. 697-703.

15. Punzi, L., et al., Value of C reactive protein in the assessment of erosive osteoarthritis of the hand. Ann Rheum Dis, 2005. 64(6): p. 955-7.

16. Penninx, B.W., et al., Inflammatory markers and physical function among older adults with knee osteoarthritis. J Rheumatol, 2004. 31(10): p. 2027-31.

17. Takahashi, M., et al., Relationship between radiographic grading of osteoarthritis and the biochemical markers for arthritis in knee osteoarthritis. Arthritis Res Ther, 2004. 6(3): p. R208-12.

18. Al-Waili, N.S., Natural honey lowers plasma glucose, C-reactive protein, homocysteine, and blood lipids in healthy, diabetic, and hyperlipidemic subjects: comparison with dextrose and sucrose. J Med Food, 2004. 7(1): p. 100-7.

19. Shambaugh, P., V. Worthington, and J.H. Herbert, Differential effects of honey, sucrose, and fructose on blood sugar levels. J Manipulative Physiol Ther, 1990. 3